Verruculogen Facts Sheet (main)

This mini website about Verruculogen was prepared by a student of BioInformatics, the Open University.

alternate names: Verruculogen

Tremorgenic mycotoxin. Potent inhibitors of Ca activated K(maxi K) channel

(from):. . A neurotoxin that blocks Ca²⁺-activated K⁺ channels. Also arrests cell cycle in M phase

Molecular formula C₂₇H₃₃N₃O₇  Molecular weight 511.6 

Gallagher, R. T.; Latch, G. C. M. (1977) Production of the tremorgenic
mycotoxins verruculogen and fumitremorgin B by Penicillium piscarium
Westling. Appl Environ Microbiol 33(3):730-731

(fromn:) Verruculogen, a potent tremorgen, and fumagillin, formerly used as a cytostatic drug, are mycotoxins found in Aspergillus fumigatus. Penicillium crustosum and Penicillium brevicompactum each produced the tremorgens roquefortine C and penitrem A. The mycotoxin standards library can be used to identify specific mold species in ambient air samples from environmental and occupational investigations.
 

about production of verruculogen  (J Gen Microbiol 1980 Apr;117(2):405-10)

 the 10 selected Verruculogen abstracts

 

1	Fate of TR-2, the hepatic metabolite of the tremorgenic mycotoxin verruculogen, in sheep.
2	Temporal separation of steps in the biosynthesis of verruculogen.
3	An intermediary role for the tremorgenic mycotoxin TR-2 in the biosynthesis of verruculogen.
4	A comparative study of sheep and pigs given the tremorgenic mycotoxins verruculogen and penitrem A.
5	Metabolism and excretion of [14C] verruculogen in a sheep.
6	Biosynthesis of radiolabeled verruculogen by Penicillium simplicissimum.
7	Metabolism of verruculogen in rats.
8	Verruculogen Produced by soil fungi in England and Wales.
9	Production of verruculogen by Penicillium estinogenum in stirred fermenters.
10	Neurobehavioral studies of tremorgenic mycotoxins verruculogen and penitrem A

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Brefeldin